NPR2

GENE INFORMATION

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Gene name

NPR2 (HGNC Symbol)

Synonyms

AMDM, ANPb, ANPRB, GUCY2B, NPRB

Description

natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) (HGNC Symbol)

Entrez gene summary

This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq, Jul 2008]

Chromosome

9 (Chromosome progress)

Cytoband

p13.3

Chromosome location (bp)

35792151 - 35809729

Ensembl

ENSG00000159899 (version 73.37)

Entrez gene

4882

UniProt

P20594 (UniProt - Evidence at protein level)

neXtProt

NX_P20594

Antibodypedia

NPR2 antibodies
 

PROTEIN VIEW

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NPR2-001
 
NPR2-003
 
NPR2-005
 
NPR2-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NPR2-001 ENSP00000341083
ENST00000342694
P20594
Show all »
Show » Show » 1047 117 Yes 1
NPR2-003 ENSP00000399204
ENST00000421267
Show » 275 30.9 No 0
NPR2-005 ENSP00000393029
ENST00000447210
H7C056
Show all »
Show » 164 19 No 0
NPR2-006 ENSP00000402902
ENST00000448821
Show » 76 8.2 No 0