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GENE INFORMATION

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Gene name

ITGB2 (HGNC Symbol)

Synonyms

CD18, LFA-1, MAC-1, MFI7

Description

integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) (HGNC Symbol)

Entrez gene summary

The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

21 (Chromosome progress)

Cytoband

q22.3

Chromosome location (bp)

46305868 - 46351904

Ensembl

ENSG00000160255 (version 69.37)

Entrez gene

3689

UniProt

P05107

neXtProt

NX_P05107

Antibodypedia

ITGB2 antibodies
 

PROTEIN VIEW

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 « 
 
ITGB2-001
 
ITGB2-002
 
ITGB2-003
 
ITGB2-004
 
ITGB2-005
 
ITGB2-008
 
ITGB2-010
 
ITGB2-013
 
ITGB2-014
 
ITGB2-015
 
ITGB2-016
 
ITGB2-017
 
ITGB2-020
 
ITGB2-021
 
ITGB2-022
 
ITGB2-024
 
ITGB2-201
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ITGB2-001 ENSP00000347279
ENST00000355153
P05107
Show all »
Show » Show » 769 84.8 Yes 1
ITGB2-002 ENSP00000380948
ENST00000397850
P05107
Show all »
Show » Show » 769 84.8 Yes 1
ITGB2-003 ENSP00000380952
ENST00000397854
A8MYE6
Show all »
Show » Show » 712 78.3 Yes 1
ITGB2-004 ENSP00000380955
ENST00000397857
P05107
Show all »
Show » Show » 769 84.8 Yes 1
ITGB2-005 ENSP00000380950
ENST00000397852
P05107
Show all »
Show » Show » 769 84.8 Yes 1
ITGB2-008 ENSP00000380944
ENST00000397846
A8MVG7
Show all »
Show » Show » 108 11.4 Yes 0
ITGB2-010 ENSP00000317697
ENST00000320216
P05107
Show all »
Show » Show » 322 35.7 No 0
ITGB2-013 ENSP00000427732
ENST00000523323
E5RGK9
Show all »
Show » 71 7.4 Yes 0
ITGB2-014 ENSP00000429683
ENST00000521995
E5RHT0
Show all »
Show » Show » 49 5.3 Yes 0
ITGB2-015 ENSP00000428413
ENST00000517563
E5RIG7
Show all »
Show » Show » 120 13 Yes 0
ITGB2-016 ENSP00000428870
ENST00000517819
E5RFI0
Show all »
Show » Show » 70 7.6 Yes 0
ITGB2-017 ENSP00000428125
ENST00000522688
E5RK54
Show all »
Show » 49 5.3 No 0
ITGB2-020 ENSP00000428434
ENST00000520389
E5RIE4
Show all »
Show » Show » 93 9.6 Yes 0
ITGB2-021 ENSP00000430901
ENST00000524251
E5RHE6
Show all »
37 4 No 0
ITGB2-022 ENSP00000428979
ENST00000522931
E5RK25
Show all »
Show » Show » 160 17.6 Yes 0
ITGB2-024 ENSP00000428503
ENST00000523663
E7EVZ9
Show all »
Show » Show » 166 18.3 Yes 0
ITGB2-201 ENSP00000303242
ENST00000302347
P05107
Show all »
Show » Show » 769 84.8 Yes 1