FTCD

GENERAL INFORMATION

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Gene name

FTCD

Gene description

Formimidoyltransferase cyclodeaminase

Protein class

Cytoskeleton related proteins
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Group enriched (kidney, liver)
GTEx:Group enriched (kidney, liver)

Protein evidence

Evidence at protein level

Protein localization

Selective cytoplasmic expression in hepatocytes and renal tubules.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining consistent with RNA expression data.

Data reliability

Supportive based on 4 antibodies.
HPA020073 , HPA030928 , HPA030929 , HPA036114
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Group enriched (kidney, liver)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (kidney, liver)

Organ

Expression



GENE INFORMATION

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Gene name

FTCD

Synonyms

Description

Formimidoyltransferase cyclodeaminase (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Mutations in this gene are associated with glutamate formiminotransferase deficiency. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Dec 2009]

Chromosome

21

Cytoband

q22.3

Chromosome location (bp)

46136262 - 46155643

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000160282 (version 78.38)

Entrez gene

10841

UniProt

O95954 (UniProt - Evidence at protein level)

neXtProt

NX_O95954

Antibodypedia

FTCD antibodies


PROTEIN BROWSER

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ENST00000291670
 
ENST00000355384
 
ENST00000397743
 
ENST00000397746
 
ENST00000397748
 
ENST00000446405
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FTCD-001 ENSP00000380854
ENST00000397746
O95954
Show all »
Show » Show » 541 58.9 No 0
FTCD-002 ENSP00000380851
ENST00000397743
B7WPK3
Show all »
Show » Show » 495 52.8 No 0
FTCD-004 ENSP00000291670
ENST00000291670
O95954
Show all »
Show » Show » 541 58.9 No 0
FTCD-005 ENSP00000380856
ENST00000397748
O95954
Show all »
Show » Show » 572 61.3 No 0
FTCD-011 ENSP00000409015
ENST00000446405
Show » Show » 133 13.3 No 0
FTCD-201 ENSP00000347545
ENST00000355384
D3DSM8
Show all »
Show » Show » 581 63.3 No 0