LSS

GENE INFORMATION

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Gene name

LSS (HGNC Symbol)

Synonyms

OSC

Description

Lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2009]

Chromosome

21

Cytoband

q22.3

Chromosome location (bp)

47608055 - 47648738

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000160285 (version 75.37)

Entrez gene

4047

UniProt

P48449 (UniProt - Evidence at protein level)

neXtProt

NX_P48449

Antibodypedia

LSS antibodies
 

PROTEIN VIEW

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LSS-001
 
LSS-002
 
LSS-005
 
LSS-008
 
LSS-010
 
LSS-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LSS-001 ENSP00000380837
ENST00000397728
P48449
Show all »
Show » Show » 732 83.3 No 0
LSS-002 ENSP00000348762
ENST00000356396
P48449
Show all »
Show » Show » 732 83.3 No 0
LSS-005 ENSP00000391368
ENST00000450351
C9J315
Show all »
Show » Show » 262 29.6 No 0
LSS-008 ENSP00000410678
ENST00000419093
Show » 136 15.3 No 0
LSS-010 ENSP00000429133
ENST00000522411
P48449
Show all »
Show » Show » 721 82.2 No 0
LSS-201 ENSP00000409191
ENST00000457828
P48449
Show all »
Show » Show » 652 74.2 No 0