ADAMTS13

GENE INFORMATION

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Gene name

ADAMTS13 (HGNC Symbol)

Synonyms

C9orf8, DKFZp434C2322, FLJ42993, MGC118899, MGC118900, TTP, vWF-CP, VWFCP

Description

ADAM metallopeptidase with thrombospondin type 1 motif, 13 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Chromosome

9 (Chromosome progress)

Cytoband

q34.2

Chromosome location (bp)

136279478 - 136324508

Ensembl

ENSG00000160323 (version 73.37)

Entrez gene

11093

UniProt

Q76LX8 (UniProt - Evidence at protein level)

neXtProt

NX_Q76LX8

Antibodypedia

ADAMTS13 antibodies
 

PROTEIN VIEW

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ADAMTS13-001
 
ADAMTS13-002
 
ADAMTS13-003
 
ADAMTS13-006
 
ADAMTS13-007
 
ADAMTS13-008
 
ADAMTS13-201
 
ADAMTS13-202
 
ADAMTS13-203
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADAMTS13-001 ENSP00000360997
ENST00000371929
Q76LX8
Show all »
Show » Show » 1427 153.6 Yes 0
ADAMTS13-002 ENSP00000347927
ENST00000355699
Q76LX8
Show all »
Show » Show » 1371 147.8 Yes 0
ADAMTS13-003 ENSP00000348997
ENST00000356589
Q76LX8
Show all »
Show » Show » 1340 144.5 Yes 0
ADAMTS13-006 ENSP00000360978
ENST00000371910
Q76LX8
Show all »
Show » Show » 223 24.5 No 0
ADAMTS13-007 ENSP00000435274
ENST00000495234
Show » Show » 344 36.7 Yes 0
ADAMTS13-008 ENSP00000435305
ENST00000474918
E7EV88
Show all »
Show » Show » 276 30 Yes 0
ADAMTS13-201 ENSP00000360979
ENST00000371911
Show » Show » 344 36.7 Yes 0
ADAMTS13-202 ENSP00000360984
ENST00000371916
E7EV88
Show all »
Show » Show » 276 30 Yes 0
ADAMTS13-203 ENSP00000444504
ENST00000536611
Q9UGQ1
Show all »
Show » 364 39.9 No 0