PCSK7

GENE INFORMATION

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Gene name

PCSK7 (HGNC Symbol)

Synonyms

LPC, PC7, PC8, SPC7

Description

proprotein convertase subtilisin/kexin type 7 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease. It is structurally related to its family members, PACE and PACE4. This protein is concentrated in the trans-Golgi network, associated with the membranes, and is not secreted. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes. Multiple alternatively spliced transcripts are described for this gene but their full length nature is not yet known. Downstream of this gene's map location at 11q23-q24, nucleotides that match part of this gene's 3' end are duplicated and inverted. A translocation breakpoint associated with lymphoma occurs between this gene and its inverted counterpart. [provided by RefSeq, Jul 2008]

Chromosome

11 (Chromosome progress)

Cytoband

q23.3

Chromosome location (bp)

117075053 - 117103241

Ensembl

ENSG00000160613 (version 73.37)

Entrez gene

9159

UniProt

Q16549 (UniProt - Evidence at protein level)

neXtProt

NX_Q16549

Antibodypedia

PCSK7 antibodies
 

PROTEIN VIEW

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PCSK7-001
 
PCSK7-004
 
PCSK7-005
 
PCSK7-006
 
PCSK7-007
 
PCSK7-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PCSK7-001 ENSP00000325917
ENST00000320934
Q16549
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Show » Show » 785 86.2 No 2
PCSK7-004 ENSP00000431181
ENST00000525027
E9PMC0
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Show » Show » 305 33 No 0
PCSK7-005 ENSP00000433252
ENST00000530269
E9PLM0
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Show » 92 9.5 No 1
PCSK7-006 ENSP00000436459
ENST00000532301
E9PLM0
Show all »
Show » 92 9.5 No 1
PCSK7-007 ENSP00000433841
ENST00000524507
E9PIW7
Show all »
Show » 113 11.8 No 1
PCSK7-201 ENSP00000441944
ENST00000540028
B3KUH2
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Show » Show » 237 26.4 No 0