SHC1

GENE INFORMATION

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Gene name

SHC1 (HGNC Symbol)

Synonyms

p66, SHC

Description

SHC (Src homology 2 domain containing) transforming protein 1 (HGNC Symbol)

Entrez gene summary

This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Chromosome

1 (Chromosome progress)

Cytoband

q21.3

Chromosome location (bp)

154934774 - 154946871

Ensembl

ENSG00000160691 (version 73.37)

Entrez gene

6464

UniProt

P29353 (UniProt - Evidence at protein level)

neXtProt

NX_P29353

Antibodypedia

SHC1 antibodies
 

PROTEIN VIEW

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 « 
 
SHC1-001
 
SHC1-002
 
SHC1-003
 
SHC1-004
 
SHC1-005
 
SHC1-006
 
SHC1-007
 
SHC1-008
 
SHC1-009
 
SHC1-010
 
SHC1-201
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SHC1-001 ENSP00000357430
ENST00000368445
P29353
Show all »
Show » Show » 583 62.8 No 0
SHC1-002 ENSP00000401303
ENST00000448116
P29353
Show all »
Show » Show » 584 62.9 No 0
SHC1-003 ENSP00000357434
ENST00000368449
P29353
Show all »
Show » Show » 354 38.6 No 0
SHC1-004 ENSP00000404908
ENST00000414115
Q5T188
Show all »
Show » 200 21.5 No 0
SHC1-005 ENSP00000398864
ENST00000444179
Q5T187
Show all »
Show » 130 14.5 No 0
SHC1-006 ENSP00000357438
ENST00000368453
P29353
Show all »
Show » Show » 474 51.7 No 0
SHC1-007 ENSP00000357435
ENST00000368450
P29353
Show all »
Show » Show » 473 51.6 No 0
SHC1-008 ENSP00000398441
ENST00000412170
Q5T182
Show all »
Show » 200 22 No 0
SHC1-009 ENSP00000396162
ENST00000366442
Q5T181
Show all »
Show » 137 14.8 No 0
SHC1-010 ENSP00000396333
ENST00000444664
Show » Show » 297 32.5 No 0
SHC1-201 ENSP00000475850
ENST00000606391
Q5T187
Show all »
Show » Show » 384 42 No 0