IL6R

GENERAL INFORMATION

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Gene name

IL6R

Gene description

Interleukin 6 receptor

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
CD markers
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Intracellular,Membrane,Secreted

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

ANTIBODY RELIABILITY

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Data reliability

Pending normal tissue annotation.
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A


PROTEIN EXPRESSION OVERVIEW

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Pending normal tissue annotation.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

IL6R (HGNC Symbol)

Synonyms

CD126

Description

Interleukin 6 receptor (HGNC Symbol)

Entrez gene summary

This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011]

Chromosome

1

Cytoband

q21.3

Chromosome location (bp)

154405193 - 154469450

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000160712 (version 78.38)

Entrez gene

3570

UniProt

P08887 (UniProt - Evidence at protein level)

neXtProt

NX_P08887

Antibodypedia

IL6R antibodies


PROTEIN BROWSER

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ENST00000344086
 
ENST00000368485
 
ENST00000476006
 
ENST00000512471
 
ENST00000515190
 
ENST00000622330
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IL6R-001 ENSP00000357470
ENST00000368485
P08887
Show all »
Show » Show » 468 51.5 Yes 1
IL6R-002 ENSP00000423668
ENST00000476006
Show » Show » 294 32.9 No 0
IL6R-003 ENSP00000340589
ENST00000344086
P08887
Show all »
Show » Show » 365 40.2 Yes 0
IL6R-004 ENSP00000423184
ENST00000512471
D6R9R8
Show all »
Show » Show » 171 18 Yes 0
IL6R-007 ENSP00000423036
ENST00000515190
Show » Show » 190 21.2 No 1
IL6R-201 ENSP00000477739
ENST00000622330
Show » Show » 352 38.8 Yes 0