IL6R

GENE INFORMATION

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Gene name

IL6R (HGNC Symbol)

Synonyms

CD126

Description

interleukin 6 receptor (HGNC Symbol)

Entrez gene summary

This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011]

Chromosome

1 (Chromosome progress)

Cytoband

q21.3

Chromosome location (bp)

154377669 - 154441926

Ensembl

ENSG00000160712 (version 73.37)

Entrez gene

3570

UniProt

P08887 (UniProt - Evidence at protein level)

neXtProt

NX_P08887

Antibodypedia

IL6R antibodies
 

PROTEIN VIEW

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IL6R-001
 
IL6R-002
 
IL6R-003
 
IL6R-004
 
IL6R-007
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IL6R-001 ENSP00000357470
ENST00000368485
P08887
Show all »
Show » Show » 468 51.5 Yes 1
IL6R-002 ENSP00000423668
ENST00000476006
Show » 294 32.9 No 0
IL6R-003 ENSP00000340589
ENST00000344086
P08887
Show all »
Show » Show » 365 40.2 Yes 0
IL6R-004 ENSP00000423184
ENST00000512471
D6R9R8
Show all »
Show » Show » 171 18 Yes 0
IL6R-007 ENSP00000423036
ENST00000515190
Show » Show » 190 21.2 No 1