CCR5

GENE INFORMATION

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Gene name

CCR5 (HGNC Symbol)

Synonyms

CC-CKR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22

Description

chemokine (C-C motif) receptor 5 (gene/pseudogene) (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

3 (Chromosome progress)

Cytoband

p21.31

Chromosome location (bp)

46411633 - 46417697

Ensembl

ENSG00000160791 (version 73.37)

Entrez gene

1234

UniProt

P51681 (UniProt - Evidence at protein level)

neXtProt

NX_P51681

Antibodypedia

CCR5 antibodies
 

PROTEIN VIEW

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CCR5-001
 
CCR5-003
 
CCR5-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CCR5-001 ENSP00000292303
ENST00000292303
P51681
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Show » Show » 352 40.5 No 7
CCR5-003 ENSP00000404881
ENST00000445772
P51681
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Show » Show » 352 40.5 No 7
CCR5-201 ENSP00000343985
ENST00000343801
P51681
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Show » Show » 352 40.5 No 7