FGFR4

GENE INFORMATION

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Gene name

FGFR4 (HGNC Symbol)

Synonyms

CD334, JTK2

Description

fibroblast growth factor receptor 4 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. [provided by RefSeq, Jul 2008]

Chromosome

5 (Chromosome progress)

Cytoband

q35.2

Chromosome location (bp)

176513887 - 176525145

Ensembl

ENSG00000160867 (version 73.37)

Entrez gene

2264

UniProt

P22455 (UniProt - Evidence at protein level)

neXtProt

NX_P22455

Antibodypedia

FGFR4 antibodies
 

PROTEIN VIEW

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 « 
 
FGFR4-001
 
FGFR4-002
 
FGFR4-003
 
FGFR4-004
 
FGFR4-005
 
FGFR4-008
 
FGFR4-009
 
FGFR4-010
 
FGFR4-012
 
FGFR4-014
 
FGFR4-201
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FGFR4-001 ENSP00000292408
ENST00000292408
P22455
Show all »
Show » Show » 802 88 Yes 1
FGFR4-002 ENSP00000377254
ENST00000393637
P22455
Show all »
Show » Show » 762 83.5 Yes 0
FGFR4-003 ENSP00000377259
ENST00000393648
J3KPQ0
Show all »
Show » Show » 734 80.5 Yes 0
FGFR4-004 ENSP00000424960
ENST00000502906
P22455
Show all »
Show » Show » 802 88 Yes 1
FGFR4-005 ENSP00000395164
ENST00000430285
B5A964
Show all »
72 7.7 Yes 0
FGFR4-008 ENSP00000422889
ENST00000513166
D6R9V0
Show all »
Show » 108 11.8 Yes 0
FGFR4-009 ENSP00000427222
ENST00000510911
D6RJD4
Show all »
Show » 87 9.5 Yes 0
FGFR4-010 ENSP00000424905
ENST00000503708
E7EWF4
Show all »
Show » 201 22.2 Yes 0
FGFR4-012 ENSP00000426492
ENST00000514472
D6RG06
Show all »
Show » 114 12.4 Yes 0
FGFR4-014 ENSP00000424670
ENST00000511076
Show » Show » 280 30.3 No 1
FGFR4-201 ENSP00000292410
ENST00000292410
P22455
Show all »
Show » Show » 762 83.5 Yes 0