SH2B2

GENERAL INFORMATION

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Gene name

SH2B2

Gene description

SH2B adaptor protein 2

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in several different tissue types.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Data reliability

Uncertain based on 1 antibody.
HPA051131
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Prostate



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

SH2B2 (HGNC Symbol)

Synonyms

APS

Description

SH2B adaptor protein 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun 2009]

Chromosome

7

Cytoband

q22.1

Chromosome location (bp)

102285091 - 102321711

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000160999 (version 78.38)

Entrez gene

10603

UniProt

O14492 (UniProt - Evidence at protein level)

neXtProt

NX_O14492

Antibodypedia

SH2B2 antibodies


PROTEIN BROWSER

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ENST00000444095
 
ENST00000536178
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SH2B2-001 ENSP00000440273
ENST00000536178
O14492
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Show » Show » 675 72.3 No 0
SH2B2-003 ENSP00000401883
ENST00000444095
Show » Show » 243 26.5 No 0