LRWD1

GENE INFORMATION

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Gene name

LRWD1 (HGNC Symbol)

Synonyms

CENP-33, DKFZp434K1815, ORCA

Description

Leucine-rich repeats and WD repeat domain containing 1 (HGNC Symbol)

Entrez gene summary

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Chromosome

7

Cytoband

q22.1

Chromosome location (bp)

102105376 - 102113615

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000161036 (version 75.37)

Entrez gene

100616367

UniProt

Q9UFC0 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UFC0

Antibodypedia

LRWD1 antibodies
 

PROTEIN VIEW

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LRWD1-001
 
LRWD1-003
 
LRWD1-004
 
LRWD1-005
 
LRWD1-007
 
LRWD1-009
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LRWD1-001 ENSP00000292616
ENST00000292616
Q9UFC0
Show all »
Show » Show » 647 70.9 No 0
LRWD1-003 ENSP00000418204
ENST00000464107
F8WBP5
Show all »
Show » 45 4.8 No 0
LRWD1-004 ENSP00000420650
ENST00000463739
F8WDB4
Show all »
Show » 27 3.1 No 0
LRWD1-005 ENSP00000417913
ENST00000476270
Show » 41 4.3 No 0
LRWD1-007 ENSP00000420729
ENST00000485808
Show » Show » 179 19.9 No 0
LRWD1-009 ENSP00000420373
ENST00000468175
Show » Show » 242 26.3 No 0