The cancer tissue page shows antibody staining in 20 different cancers. The overall cancer tissue staining statistics shows the fraction of patient samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right), using all the available antibodies to the protein targets encoded by this gene. The assay and annotation is described here.
The cancers can be ordered histologically or alphabetically.
For each cancer, the staining for each available antibody is reported as the fraction of samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right). The lenght of the bar represents the number of patient samples analysed (max=12 patients). By clicking on a cancer tissue, the detailed staining data for that cancer is available, including annotated images.
At the bottom of this page, a summary for the cancer staining for each antibody is given, together with the immunohistochemistry validation score for that antibody.
Most malignant cells showed weak to moderate cytoplasmic staining. Endometrial, cervical, pancreatic, liver, prostate and ovarian cancers displayed strong cytoplasmic positivity.
Most malignancies displayed moderate cytoplasmic positivity. Liver and thyroid cancers as well as several cases of malignant lymphomas and colorectal cancers were strongly stained. A majority of malignant carcinoids, lung, skin and stomach cancers were weakly stained or negative.
Liver cancers were strongly stained. Most other malignancies were weakly stained or negative.
Moderate to strong cytoplasmic immunoreactivity was displayed in liver carcinomas. Prostate, colorectal, gastric, lung and pancreatic cancers showed weak to moderate staining. Remaining malignant cells were weakly stained or negative.
Validation
Two (or more) antibodies yielding partly similar staining patterns which are consistent with gene/protein characterization data
Two (or more) antibodies yielding partly similar staining patterns which are partly consistent with gene/protein characterization data or consistent with limited gene/protein characterization data
Two (or more) antibodies yielding partly similar staining patterns which are consistent with gene/protein characterization data
Two (or more) antibodies yielding partly similar staining patterns which are consistent with gene/protein characterization data
