NXF1

GENERAL INFORMATION

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Gene name

NXF1

Gene description

Nuclear RNA export factor 1

Protein class

Predicted intracellular proteins
Transporters

Predicted localization

Intracellular

Number of transcripts

8
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous nuclear expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 2 antibodies.
HPA061593 , CAB016327
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

NXF1 (HGNC Symbol)

Synonyms

DKFZp667O0311, Mex67, TAP

Description

Nuclear RNA export factor 1 (HGNC Symbol)

Entrez gene summary

This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

q12.3

Chromosome location (bp)

62792123 - 62806302

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000162231 (version 78.38)

Entrez gene

10482

UniProt

Q9UBU9 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UBU9

Antibodypedia

NXF1 antibodies


PROTEIN BROWSER

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ENST00000294172
 
ENST00000527902
 
ENST00000530875
 
ENST00000531131
 
ENST00000531474
 
ENST00000531709
 
ENST00000532297
 
ENST00000533671
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NXF1-001 ENSP00000436679
ENST00000532297
Q9UBU9
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Show » Show » 619 70.2 No 0
NXF1-002 ENSP00000437296
ENST00000531474
E9PMV7
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Show » 63 7.3 No 0
NXF1-003 ENSP00000435742
ENST00000530875
E9PIN3
Show all »
Show » Show » 603 68.1 No 0
NXF1-004 ENSP00000477375
ENST00000531131
B4E227
Show all »
Show » Show » 219 24.7 No 0
NXF1-006 ENSP00000453885
ENST00000531709
Q9UBU9
Show all »
Show » Show » 356 40.5 No 0
NXF1-012 ENSP00000431381
ENST00000533671
E9PLA7
Show all »
Show » Show » 115 13.2 No 0
NXF1-013 ENSP00000434301
ENST00000527902
A0A024R5A9
Show all »
Show » Show » 124 13.5 No 0
NXF1-201 ENSP00000294172
ENST00000294172
Q9UBU9
Show all »
Show » Show » 619 70.2 No 0