NXF1

GENE INFORMATION

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Gene name

NXF1 (HGNC Symbol)

Synonyms

DKFZp667O0311, Mex67, TAP

Description

nuclear RNA export factor 1 (HGNC Symbol)

Entrez gene summary

This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Chromosome

11 (Chromosome progress)

Cytoband

q12.3

Chromosome location (bp)

62559595 - 62573774

Ensembl

ENSG00000162231 (version 73.37)

Entrez gene

10482

UniProt

Q9UBU9 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UBU9

Antibodypedia

NXF1 antibodies
 

PROTEIN VIEW

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NXF1-001
 
NXF1-002
 
NXF1-003
 
NXF1-006
 
NXF1-010
 
NXF1-012
 
NXF1-013
 
NXF1-201
 
NXF1-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NXF1-001 ENSP00000436679
ENST00000532297
Q9UBU9
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Show » Show » 619 70.2 No 0
NXF1-002 ENSP00000437296
ENST00000531474
E9PMV7
Show all »
Show » 63 7.3 No 0
NXF1-003 ENSP00000435742
ENST00000530875
E9PIN3
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Show » Show » 603 68.1 No 0
NXF1-006 ENSP00000453885
ENST00000531709
Q9UBU9
Show all »
Show » Show » 356 40.5 No 0
NXF1-010 ENSP00000432530
ENST00000525576
E9PQA4
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76 8.6 No 0
NXF1-012 ENSP00000431381
ENST00000533671
E9PLA7
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Show » 115 13.2 No 0
NXF1-013 ENSP00000434301
ENST00000527902
Show » 124 13.5 No 0
NXF1-201 ENSP00000294172
ENST00000294172
Q9UBU9
Show all »
Show » Show » 619 70.2 No 0
NXF1-202 ENSP00000408864
ENST00000439713
Q9UBU9
Show all »
Show » Show » 356 40.5 No 0