LRP5

GENE INFORMATION

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Gene name

LRP5 (HGNC Symbol)

Synonyms

BMND1, EVR1, HBM, LR3, LRP7, OPPG, OPS, OPTA1, VBCH2

Description

Low density lipoprotein receptor-related protein 5 (HGNC Symbol)

Entrez gene summary

This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Chromosome

11

Cytoband

q13.2

Chromosome location (bp)

68080077 - 68216743

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000162337 (version 75.37)

Entrez gene

4041

UniProt

O75197 (UniProt - Evidence at protein level)

neXtProt

NX_O75197

Antibodypedia

LRP5 antibodies
 

PROTEIN VIEW

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LRP5-001
 
LRP5-002
 
LRP5-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LRP5-001 ENSP00000294304
ENST00000294304
O75197
Show all »
Show » Show » 1615 179.1 Yes 1
LRP5-002 ENSP00000436652
ENST00000529993
E9PHY1
Show all »
Show » Show » 471 52.4 Yes 0
LRP5-005 ENSP00000435315
ENST00000529702
Show » 172 18.7 No 0