LRP5

GENE INFORMATION

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Gene name

LRP5 (HGNC Symbol)

Synonyms

BMND1, EVR1, HBM, LR3, LRP7, OPPG, OPS, OPTA1, VBCH2

Description

low density lipoprotein receptor-related protein 5 (HGNC Symbol)

Entrez gene summary

This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. [provided by RefSeq, Nov 2009]

Chromosome

11 (Chromosome progress)

Cytoband

q13.2

Chromosome location (bp)

68080077 - 68216743

Ensembl

ENSG00000162337 (version 73.37)

Entrez gene

4041

UniProt

O75197 (UniProt - Evidence at protein level)

neXtProt

NX_O75197

Antibodypedia

LRP5 antibodies
 

PROTEIN VIEW

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LRP5-001
 
LRP5-002
 
LRP5-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LRP5-001 ENSP00000294304
ENST00000294304
O75197
Show all »
Show » Show » 1615 179.1 Yes 1
LRP5-002 ENSP00000436652
ENST00000529993
E9PHY1
Show all »
Show » Show » 471 52.4 Yes 0
LRP5-005 ENSP00000435315
ENST00000529702
172 18.7 No 0