TPCN2

GENE INFORMATION

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Gene name

TPCN2 (HGNC Symbol)

Synonyms

TPC2

Description

two pore segment channel 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. This ubiquitously expressed gene has elevated expression in liver and kidney. Two common nonsynonymous SNPs in this gene strongly associate with blond versus brown hair pigmentation.[provided by RefSeq, Dec 2009]

Chromosome

11 (Chromosome progress)

Cytoband

q13.3

Chromosome location (bp)

68816365 - 68858072

Ensembl

ENSG00000162341 (version 73.37)

Entrez gene

219931

UniProt

Q8NHX9 (UniProt - Evidence at protein level)

neXtProt

NX_Q8NHX9

Antibodypedia

TPCN2 antibodies
 

PROTEIN VIEW

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TPCN2-001
 
TPCN2-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TPCN2-001 ENSP00000294309
ENST00000294309
Q8NHX9
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Show » Show » 752 85.2 No >9
TPCN2-003 ENSP00000445551
ENST00000542467
E7ETX0
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Show » Show » 570 64.6 No 7