PRKAA2

GENE INFORMATION

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Gene name

PRKAA2 (HGNC Symbol)

Synonyms

AMPK, AMPKa2, PRKAA

Description

protein kinase, AMP-activated, alpha 2 catalytic subunit (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

p32.2

Chromosome location (bp)

57110995 - 57181008

Ensembl

ENSG00000162409 (version 73.37)

Entrez gene

5563

UniProt

P54646 (UniProt - Evidence at protein level)

neXtProt

NX_P54646

Antibodypedia

PRKAA2 antibodies
 

PROTEIN VIEW

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PRKAA2-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PRKAA2-001 ENSP00000360290
ENST00000371244
P54646
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