JAK1

GENE INFORMATION

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Gene name

JAK1 (HGNC Symbol)

Synonyms

JAK1A, JAK1B, JTK3

Description

Janus kinase 1 (HGNC Symbol)

Entrez gene summary

Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

p31.3

Chromosome location (bp)

65298912 - 65432187

Ensembl

ENSG00000162434 (version 73.37)

Entrez gene

3716

UniProt

P23458 (UniProt - Evidence at protein level)

neXtProt

NX_P23458

Antibodypedia

JAK1 antibodies
 

PROTEIN VIEW

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JAK1-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

JAK1-001 ENSP00000343204
ENST00000342505
P23458
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