ALPL

GENERAL INFORMATION

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Gene name

ALPL

Gene description

Alkaline phosphatase, liver/bone/kidney

Protein class

Cancer-related genes
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Intracellular,Membrane,Secreted

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (kidney, lung)
GTEx:Tissue enhanced (lung)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in several cell types, with highest expression in adrenal gland.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 3 antibodies.
HPA007105 , HPA008765 , CAB020829
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (kidney, lung)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (lung)

Organ

Expression



GENE INFORMATION

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Gene name

ALPL (HGNC Symbol)

Synonyms

HOPS, TNSALP

Description

Alkaline phosphatase, liver/bone/kidney (HGNC Symbol)

Entrez gene summary

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

Chromosome

1

Cytoband

p36.12

Chromosome location (bp)

21509372 - 21578412

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000162551 (version 78.38)

Entrez gene

249

UniProt

P05186 (UniProt - Evidence at protein level)

neXtProt

NX_P05186

Antibodypedia

ALPL antibodies


PROTEIN BROWSER

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ENST00000374830
 
ENST00000374832
 
ENST00000374840
 
ENST00000539907
 
ENST00000540617
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ALPL-001 ENSP00000363973
ENST00000374840
P05186
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Show » Show » 524 57.3 Yes 0
ALPL-002 ENSP00000363965
ENST00000374832
P05186
Show all »
Show » Show » 524 57.3 Yes 0
ALPL-004 ENSP00000363963
ENST00000374830
B1ANL0
Show all »
Show » Show » 216 23 No 0
ALPL-006 ENSP00000437674
ENST00000539907
P05186
Show all »
Show » Show » 447 48.9 No 1
ALPL-007 ENSP00000442672
ENST00000540617
P05186
Show all »
Show » Show » 469 51 No 0