WNT4

GENE INFORMATION

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Gene name

WNT4 (HGNC Symbol)

Synonyms

WNT-4

Description

wingless-type MMTV integration site family, member 4 (HGNC Symbol)

Entrez gene summary

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

p36.12

Chromosome location (bp)

22443798 - 22470462

Ensembl

ENSG00000162552 (version 73.37)

Entrez gene

54361

UniProt

P56705 (UniProt - Evidence at protein level)

neXtProt

NX_P56705

Antibodypedia

WNT4 antibodies
 

PROTEIN VIEW

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WNT4-001
 
WNT4-002
 
WNT4-003
 
WNT4-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

WNT4-001 ENSP00000290167
ENST00000290167
P56705
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Show » Show » 351 39.1 Yes 1
WNT4-002 ENSP00000403334
ENST00000415567
B1AJZ6
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Show » 150 16.5 No 0
WNT4-003 ENSP00000388925
ENST00000441048
B1AJZ6
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Show » 52 6 No 0
WNT4-201 ENSP00000441033
ENST00000542383
B4DJF9
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Show » Show » 296 33 No 0