NEXN

GENERAL INFORMATION

? »

Gene name

NEXN

Gene description

Nexilin (F actin binding protein)

Protein class

Cytoskeleton related proteins
Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Tissue enhanced (heart muscle, skeletal muscle)
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most normal tissues displayed weak to moderate cytoplasmic positivity with additional membranous staining in a few cases. Megakaryocytes and trophoblast were distinctly stained.

ANTIBODY RELIABILITY

? »

Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA011185
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

? »

Organ

Expression



RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Tissue enhanced (heart muscle, skeletal muscle)

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

? »

Gene name

NEXN (HGNC Symbol)

Synonyms

NELIN, nexilin

Description

Nexilin (F actin binding protein) (HGNC Symbol)

Entrez gene summary

This gene encodes a filamentous actin-binding protein that may function in cell adhesion and migration. Mutations in this gene have been associated with dilated cardiomyopathy, also known as CMD1CC. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]

Chromosome

1

Cytoband

p31.1

Chromosome location (bp)

77888513 - 77943895

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000162614 (version 78.38)

Entrez gene

91624

UniProt

Q0ZGT2 (UniProt - Evidence at protein level)

neXtProt

NX_Q0ZGT2

Antibodypedia

NEXN antibodies


PROTEIN BROWSER

? »
 
 
 
ENST00000330010
 
ENST00000334785
 
ENST00000342754
 
ENST00000401035
 
ENST00000440324
 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NEXN-001 ENSP00000333938
ENST00000334785
Q0ZGT2
Show all »
Show » Show » 675 80.7 No 0
NEXN-002 ENSP00000383814
ENST00000401035
E7ETM8
Show all »
Show » 321 38.4 No 0
NEXN-003 ENSP00000411902
ENST00000440324
E7EUA0
Show all »
Show » 435 52.7 No 0
NEXN-005 ENSP00000343928
ENST00000342754
Show » Show » 576 68.8 No 0
NEXN-201 ENSP00000327363
ENST00000330010
Q0ZGT2
Show all »
Show » Show » 611 72.7 No 0