IGSF8

GENE INFORMATION

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Gene name

IGSF8 (HGNC Symbol)

Synonyms

CD316, CD81P3, EWI2, PGRL

Description

immunoglobulin superfamily, member 8 (HGNC Symbol)

Entrez gene summary

This gene encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Members of this family contain a single transmembrane domain, an EWI (Glu-Trp-Ile)-motif and a variable number of immunoglobulin domains. This protein interacts with the tetraspanins CD81 and CD9 and may regulate their role in certain cellular functions including cell migration and viral infection. The encoded protein may also function as a tumor suppressor by inhibiting the proliferation of certain cancers. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]

Chromosome

1 (Chromosome progress)

Cytoband

q23.2

Chromosome location (bp)

160061130 - 160068733

Ensembl

ENSG00000162729 (version 73.37)

Entrez gene

93185

UniProt

Q969P0 (UniProt - Evidence at protein level)

neXtProt

NX_Q969P0

Antibodypedia

IGSF8 antibodies
 

PROTEIN VIEW

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IGSF8-001
 
IGSF8-002
 
IGSF8-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IGSF8-001 ENSP00000316664
ENST00000314485
Q969P0
Show all »
Show » Show » 613 65 Yes 1
IGSF8-002 ENSP00000397464
ENST00000448417
C9J8Z4
Show all »
Show » Show » 301 32.3 Yes 0
IGSF8-003 ENSP00000357065
ENST00000368086
Q969P0
Show all »
Show » Show » 613 65 Yes 1