DDR2

GENE INFORMATION

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Gene name

DDR2 (HGNC Symbol)

Synonyms

NTRKR3, TKT, TYRO10

Description

discoidin domain receptor tyrosine kinase 2 (HGNC Symbol)

Entrez gene summary

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

q23.3

Chromosome location (bp)

162601163 - 162750237

Ensembl

ENSG00000162733 (version 73.37)

Entrez gene

4921

UniProt

Q16832 (UniProt - Evidence at protein level)

neXtProt

NX_Q16832

Antibodypedia

DDR2 antibodies
 

PROTEIN VIEW

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DDR2-001
 
DDR2-002
 
DDR2-003
 
DDR2-004
 
DDR2-005
 
DDR2-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DDR2-001 ENSP00000356899
ENST00000367922
Q16832
Show all »
Show » Show » 855 96.7 Yes 1
DDR2-002 ENSP00000356898
ENST00000367921
Q16832
Show all »
Show » Show » 855 96.7 Yes 1
DDR2-003 ENSP00000391310
ENST00000415555
Q5T244
Show all »
Show » Show » 148 16.5 Yes 0
DDR2-004 ENSP00000400309
ENST00000446985
Q5T245
Show all »
Show » Show » 130 14.4 Yes 0
DDR2-005 ENSP00000417030
ENST00000458105
Q5T241
Show all »
Show » 166 18.7 No 1
DDR2-006 ENSP00000396864
ENST00000433757
Show » 171 18.9 No 0