VANGL2

GENERAL INFORMATION

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Gene name

VANGL2

Gene description

VANGL planar cell polarity protein 2

Protein class

Disease related genes
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (skin)
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

RNA data suggests expression in skin. RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

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Data reliability
description

Pending external verification. Presumed off target binding observed and disregarded.

Data reliability

Uncertain based on 1 antibody.
HPA027043
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (skin)

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

VANGL2 (HGNC Symbol)

Synonyms

KIAA1215, LPP1, LTAP, MGC119403, MGC119404, STB1, STBM, STBM1

Description

VANGL planar cell polarity protein 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate. [provided by RefSeq, Sep 2011]

Chromosome

1

Cytoband

q23.2

Chromosome location (bp)

160400586 - 160428678

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000162738 (version 78.38)

Entrez gene

57216

UniProt

Q9ULK5 (UniProt - Evidence at protein level)

neXtProt

NX_Q9ULK5

Antibodypedia

VANGL2 antibodies


PROTEIN BROWSER

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ENST00000368061
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

VANGL2-001 ENSP00000357040
ENST00000368061
Q9ULK5
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