KCNJ3

GENE INFORMATION

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Gene name

KCNJ3 (HGNC Symbol)

Synonyms

GIRK1, KGA, Kir3.1

Description

potassium inwardly-rectifying channel, subfamily J, member 3 (HGNC Symbol)

Entrez gene summary

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, Down's syndrome, ataxia, and Parkinson's disease. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, May 2012]

Chromosome

2 (Chromosome progress)

Cytoband

q24.1

Chromosome location (bp)

155554811 - 155714863

Ensembl

ENSG00000162989 (version 73.37)

Entrez gene

3760

UniProt

P48549 (UniProt - Evidence at protein level)

neXtProt

NX_P48549

Antibodypedia

KCNJ3 antibodies
 

PROTEIN VIEW

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KCNJ3-001
 
KCNJ3-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KCNJ3-001 ENSP00000295101
ENST00000295101
P48549
Show all »
Show » Show » 501 56.6 No 2
KCNJ3-201 ENSP00000438410
ENST00000544049
P48549
Show all »
Show » Show » 235 26.8 No 2