MRPS18C

GENE INFORMATION

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Gene name

MRPS18C (HGNC Symbol)

Synonyms

CGI-134, FLJ11146, FLJ22967, MRPS18-1

Description

mitochondrial ribosomal protein S18C (HGNC Symbol)

Entrez gene summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. Pseudogenes corresponding to this gene are found on chromosomes 8p, 12p, 15q, and 22q. [provided by RefSeq, Jul 2008]

Chromosome

4 (Chromosome progress)

Cytoband

q21.23

Chromosome location (bp)

84377085 - 84390888

Ensembl

ENSG00000163319 (version 73.37)

Entrez gene

51023

UniProt

Q9Y3D5 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y3D5

Antibodypedia

MRPS18C antibodies
 

PROTEIN VIEW

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MRPS18C-001
 
MRPS18C-003
 
MRPS18C-005
 
MRPS18C-006
 
MRPS18C-010
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MRPS18C-001 ENSP00000295491
ENST00000295491
Q9Y3D5
Show all »
Show » Show » 142 15.8 No 0
MRPS18C-003 ENSP00000427169
ENST00000507019
D6RCM2
Show all »
Show » 114 12.6 No 0
MRPS18C-005 ENSP00000425268
ENST00000505719
H0Y9W2
Show all »
Show » 92 10.3 No 0
MRPS18C-006 ENSP00000426930
ENST00000507349
D6RE70
Show all »
68 7.5 No 0
MRPS18C-010 ENSP00000427014
ENST00000509970
Show » 113 12.4 No 0