CCKAR

GENERAL INFORMATION

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Gene name

CCKAR

Gene description

Cholecystokinin A receptor

Protein class

FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Group enriched (gallbladder, stomach)
GTEx:Tissue enriched (stomach)

Protein evidence

Evidence at protein level

Protein localization

Moderate to strong cytoplasmic positivity was displayed in several tissues, including gall bladder and gastrointestinal tract. Cells of the CNS and peripheral nerves mainly showed nuclear positivity. Neuropil was distinctly stained. Squamous epithelia and lymphoid tissues were weakly stained or negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
CAB005619
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Gallbladder

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Group enriched (gallbladder, stomach)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (stomach)

Organ

Expression



GENE INFORMATION

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Gene name

CCKAR

Synonyms

Description

Cholecystokinin A receptor (HGNC Symbol)

Entrez gene summary

This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine. [provided by RefSeq, Jul 2008]

Chromosome

4

Cytoband

p15.2

Chromosome location (bp)

26481400 - 26490462

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000163394 (version 78.38)

Entrez gene

886

UniProt

P32238 (UniProt - Evidence at protein level)

neXtProt

NX_P32238

Antibodypedia

CCKAR antibodies


PROTEIN BROWSER

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ENST00000295589
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CCKAR-001 ENSP00000295589
ENST00000295589
P32238
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