ATP1A1

GENE INFORMATION

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Gene name

ATP1A1

Synonyms

Description

ATPase, Na+/K+ transporting, alpha 1 polypeptide (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Chromosome

1 (Chromosome progress)

Cytoband

p13.1

Chromosome location (bp)

116915290 - 116952883

Ensembl

ENSG00000163399 (version 73.37)

Entrez gene

476

UniProt

P05023 (UniProt - Evidence at protein level)

neXtProt

NX_P05023

Antibodypedia

ATP1A1 antibodies
 

PROTEIN VIEW

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ATP1A1-001
 
ATP1A1-002
 
ATP1A1-006
 
ATP1A1-008
 
ATP1A1-201
 
ATP1A1-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATP1A1-001 ENSP00000295598
ENST00000295598
P05023
Show all »
Show » Show » 1023 112.9 No >9
ATP1A1-002 ENSP00000358506
ENST00000369494
Q5TC01
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Show » Show » 144 16.1 No 2
ATP1A1-006 ENSP00000396236
ENST00000440951
Q5TC05
Show all »
Show » Show » 157 18.2 No 3
ATP1A1-008 ENSP00000400124
ENST00000418797
Q5TC02
Show all »
Show » Show » 106 11.8 No 1
ATP1A1-201 ENSP00000358508
ENST00000369496
P05023
Show all »
Show » Show » 992 109.5 No >9
ATP1A1-202 ENSP00000445306
ENST00000537345
P05023
Show all »
Show » Show » 1023 113 No >9