IGFBP7

GENE INFORMATION

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Gene name

IGFBP7 (HGNC Symbol)

Synonyms

FSTL2, IGFBP-7, MAC25, PSF

Description

insulin-like growth factor binding protein 7 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011]

Chromosome

4 (Chromosome progress)

Cytoband

q12

Chromosome location (bp)

57896939 - 57976551

Ensembl

ENSG00000163453 (version 73.37)

Entrez gene

3490

UniProt

Q16270 (UniProt - Evidence at protein level)

neXtProt

NX_Q16270

Antibodypedia

IGFBP7 antibodies
 

PROTEIN VIEW

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IGFBP7-001
 
IGFBP7-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IGFBP7-001 ENSP00000295666
ENST00000295666
Q16270
Show all »
Show » Show » 282 29.1 Yes 0
IGFBP7-201 ENSP00000444146
ENST00000537922
Q16270
Show all »
Show » Show » 279 28.9 Yes 0