CRYBA2

GENERAL INFORMATION

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Gene name

CRYBA2

Gene description

Crystallin, beta A2

Protein class

Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (stomach)
GTEx:Tissue enhanced (pancreas, testis)

Protein evidence

Evidence at protein level

Protein localization

RNA data suggests expression in endocrine pancreas. RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

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Data reliability
description

Pending external verification. Pending additional tissues.

Data reliability

Uncertain based on 1 antibody.
HPA045913
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (stomach)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (pancreas, testis)

Organ

Expression



GENE INFORMATION

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Gene name

CRYBA2

Synonyms

Description

Crystallin, beta A2 (HGNC Symbol)

Entrez gene summary

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of the vertebrate eye, which function to maintain the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also defined as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group but absent in the acidic group). Beta-crystallins form aggregates of different sizes and are able to form homodimers through self-association or heterodimers with other beta-crystallins. This gene is a beta acidic group member. Three alternatively spliced transcript variants encoding identical proteins have been reported. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q35

Chromosome location (bp)

218990189 - 218993421

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000163499 (version 78.38)

Entrez gene

1412

UniProt

P53672 (UniProt - Evidence at protein level)

neXtProt

NX_P53672

Antibodypedia

CRYBA2 antibodies


PROTEIN BROWSER

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ENST00000295728
 
ENST00000392096
 
ENST00000453769
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CRYBA2-001 ENSP00000375946
ENST00000392096
P53672
Show all »
Show » Show » 197 22.1 No 0
CRYBA2-002 ENSP00000295728
ENST00000295728
P53672
Show all »
Show » Show » 197 22.1 No 0
CRYBA2-003 ENSP00000395120
ENST00000453769
C9JDH2
Show all »
Show » 129 14.4 No 0