CRYBA2

GENE INFORMATION

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Gene name

CRYBA2

Synonyms

Description

crystallin, beta A2 (HGNC Symbol)

Entrez gene summary

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of the vertebrate eye, which function to maintain the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also defined as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group but absent in the acidic group). Beta-crystallins form aggregates of different sizes and are able to form homodimers through self-association or heterodimers with other beta-crystallins. This gene is a beta acidic group member. Three alternatively spliced transcript variants encoding identical proteins have been reported. [provided by RefSeq, Jul 2008]

Chromosome

2 (Chromosome progress)

Cytoband

q35

Chromosome location (bp)

219854911 - 219858143

Ensembl

ENSG00000163499 (version 73.37)

Entrez gene

1412

UniProt

P53672 (UniProt - Evidence at protein level)

neXtProt

NX_P53672

Antibodypedia

CRYBA2 antibodies
 

PROTEIN VIEW

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CRYBA2-001
 
CRYBA2-002
 
CRYBA2-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CRYBA2-001 ENSP00000375946
ENST00000392096
P53672
Show all »
Show » 197 22.1 No 0
CRYBA2-002 ENSP00000295728
ENST00000295728
P53672
Show all »
Show » 197 22.1 No 0
CRYBA2-003 ENSP00000395120
ENST00000453769
C9JDH2
Show all »
Show » 129 14.4 No 0