TGFBR2

GENE INFORMATION

? »

Gene name

TGFBR2 (HGNC Symbol)

Synonyms

MFS2

Description

transforming growth factor, beta receptor II (70/80kDa) (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

3 (Chromosome progress)

Cytoband

p24.1

Chromosome location (bp)

30647994 - 30735634

Ensembl

ENSG00000163513 (version 73.37)

Entrez gene

7048

UniProt

P37173 (UniProt - Evidence at protein level)

neXtProt

NX_P37173

Antibodypedia

TGFBR2 antibodies
 

PROTEIN VIEW

? »
 
 
 
TGFBR2-001
 
TGFBR2-002
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TGFBR2-001 ENSP00000295754
ENST00000295754
P37173
Show all »
Show » Show » 567 64.6 Yes 1
TGFBR2-002 ENSP00000351905
ENST00000359013
P37173
Show all »
Show » Show » 592 67.5 No 1