PRKCI

GENE INFORMATION

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Gene name

PRKCI (HGNC Symbol)

Synonyms

DXS1179E, PKCI

Description

protein kinase C, iota (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008]

Chromosome

3 (Chromosome progress)

Cytoband

q26.2

Chromosome location (bp)

169940153 - 170023769

Ensembl

ENSG00000163558 (version 73.37)

Entrez gene

5584

UniProt

P41743 (UniProt - Evidence at protein level)

neXtProt

NX_P41743

Antibodypedia

PRKCI antibodies
 

PROTEIN VIEW

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PRKCI-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PRKCI-001 ENSP00000295797
ENST00000295797
P41743
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