CCR1

GENE INFORMATION

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Gene name

CCR1 (HGNC Symbol)

Synonyms

CD191, CKR-1, CMKBR1, MIP1aR, SCYAR1

Description

chemokine (C-C motif) receptor 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]

Chromosome

3 (Chromosome progress)

Cytoband

p21.31

Chromosome location (bp)

46243200 - 46249887

Ensembl

ENSG00000163823 (version 73.37)

Entrez gene

1230

UniProt

P32246 (UniProt - Evidence at protein level)

neXtProt

NX_P32246

Antibodypedia

CCR1 antibodies
 

PROTEIN VIEW

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CCR1-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CCR1-001 ENSP00000296140
ENST00000296140
P32246
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