BAP1

GENE INFORMATION

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Gene name

BAP1 (HGNC Symbol)

Synonyms

hucep-6, KIAA0272, UCHL2

Description

BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) (HGNC Symbol)

Entrez gene summary

This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma. [provided by RefSeq, May 2013]

Chromosome

3 (Chromosome progress)

Cytoband

p21.1

Chromosome location (bp)

52435029 - 52444366

Ensembl

ENSG00000163930 (version 73.37)

Entrez gene

8314

UniProt

Q92560 (UniProt - Evidence at protein level)

neXtProt

NX_Q92560

Antibodypedia

BAP1 antibodies
 

PROTEIN VIEW

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BAP1-001
 
BAP1-004
 
BAP1-010
 
BAP1-014
 
BAP1-015
 
BAP1-016
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BAP1-001 ENSP00000417132
ENST00000460680
Q92560
Show all »
Show » Show » 729 80.4 No 0
BAP1-004 ENSP00000419709
ENST00000490917
F8WEY5
Show all »
Show » 41 4.6 No 0
BAP1-010 ENSP00000296288
ENST00000296288
F8W6N3
Show all »
Show » 711 78.2 No 0
BAP1-014 ENSP00000420647
ENST00000478368
H0Y8E8
Show all »
Show » 253 28.2 No 0
BAP1-015 ENSP00000418320
ENST00000469613
129 14.6 No 0
BAP1-016 ENSP00000417776
ENST00000470173
C9J7L9
Show all »
Show » 112 12.3 No 0