SGMS2

GENERAL INFORMATION

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Gene name

SGMS2

Gene description

Sphingomyelin synthase 2

Protein class

Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General membranous expression in essentially all cell types except in squamous epithelium.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 1 antibody.
HPA015076
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

SGMS2 (HGNC Symbol)

Synonyms

MGC26963, SMS2

Description

Sphingomyelin synthase 2 (HGNC Symbol)

Entrez gene summary

Sphingomyelin, a major component of cell and Golgi membranes, is made by the transfer of phosphocholine from phosphatidylcholine onto ceramide, with diacylglycerol as a side product. The protein encoded by this gene is an enzyme that catalyzes this reaction primarily at the cell membrane. The synthesis is reversible, and this enzyme can catalyze the reaction in either direction. The encoded protein is required for cell growth. Three transcript variants encoding the same protein have been found for this gene. There is evidence for more variants, but the full-length nature of their transcripts has not been determined.[provided by RefSeq, Oct 2008]

Chromosome

4

Cytoband

q25

Chromosome location (bp)

107824563 - 107915047

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000164023 (version 78.38)

Entrez gene

166929

UniProt

Q8NHU3 (UniProt - Evidence at protein level)

neXtProt

NX_Q8NHU3

Antibodypedia

SGMS2 antibodies


PROTEIN BROWSER

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ENST00000359079
 
ENST00000394684
 
ENST00000394686
 
ENST00000503385
 
ENST00000503862
 
ENST00000506993
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SGMS2-001 ENSP00000378176
ENST00000394684
Q8NHU3
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Show » Show » 365 42.3 No 6
SGMS2-002 ENSP00000351981
ENST00000359079
Q8NHU3
Show all »
Show » Show » 365 42.3 No 6
SGMS2-003 ENSP00000378178
ENST00000394686
Q8NHU3
Show all »
Show » Show » 365 42.3 No 6
SGMS2-006 ENSP00000428176
ENST00000503862
E5RJU3
Show all »
Show » Show » 125 14.4 No 3
SGMS2-009 ENSP00000428294
ENST00000506993
E5RJ63
Show all »
Show » 34 3.9 No 0
SGMS2-010 ENSP00000430172
ENST00000503385
E5RGG5
Show all »
Show » 44 4.9 No 0