APEH

GENE INFORMATION

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Gene name

APEH (HGNC Symbol)

Synonyms

D3F15S2, D3S48E, DNF15S2

Description

acylaminoacyl-peptide hydrolase (HGNC Symbol)

Entrez gene summary

This gene encodes the enzyme acylpeptide hydrolase, which catalyzes the hydrolysis of the terminal acetylated amino acid preferentially from small acetylated peptides. The acetyl amino acid formed by this hydrolase is further processed to acetate and a free amino acid by an aminoacylase. This gene is located within the same region of chromosome 3 (3p21) as the aminoacylase gene, and deletions at this locus are also associated with a decrease in aminoacylase activity. The acylpeptide hydrolase is a homotetrameric protein of 300 kDa with each subunit consisting of 732 amino acid residues. It can play an important role in destroying oxidatively damaged proteins in living cells. Deletions of this gene locus are found in various types of carcinomas, including small cell lung carcinoma and renal cell carcinoma. [provided by RefSeq, Jul 2008]

Chromosome

3 (Chromosome progress)

Cytoband

p21.31

Chromosome location (bp)

49711435 - 49721396

Ensembl

ENSG00000164062 (version 73.37)

Entrez gene

327

UniProt

P13798 (UniProt - Evidence at protein level)

neXtProt

NX_P13798

Antibodypedia

APEH antibodies
 

PROTEIN VIEW

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APEH-001
 
APEH-002
 
APEH-003
 
APEH-005
 
APEH-009
 
APEH-012
 
APEH-013
 
APEH-014
 
APEH-016
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

APEH-001 ENSP00000296456
ENST00000296456
P13798
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Show » Show » 732 81.2 No 0
APEH-002 ENSP00000415862
ENST00000438011
C9JIF9
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Show » Show » 737 81.7 No 0
APEH-003 ENSP00000414369
ENST00000449966
C9JLK2
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Show » 232 26 No 0
APEH-005 ENSP00000410149
ENST00000446089
F8WBC4
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58 6.4 No 0
APEH-009 ENSP00000401871
ENST00000447436
F8WEH5
Show all »
50 5.5 No 0
APEH-012 ENSP00000410366
ENST00000457042
H7C393
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Show » 284 31.9 No 0
APEH-013 ENSP00000404353
ENST00000447541
H7C273
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54 5.9 No 0
APEH-014 ENSP00000402365
ENST00000442186
H7C1U0
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Show » 308 34.6 No 0
APEH-016 ENSP00000438180
ENST00000469362
H0YFE5
Show all »
47 5.4 No 0