F2RL1

GENE INFORMATION

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Gene name

F2RL1 (HGNC Symbol)

Synonyms

GPR11, PAR2

Description

coagulation factor II (thrombin) receptor-like 1 (HGNC Symbol)

Entrez gene summary

Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence. [provided by RefSeq, Jul 2008]

Chromosome

5 (Chromosome progress)

Cytoband

q13.3

Chromosome location (bp)

76114758 - 76131140

Ensembl

ENSG00000164251 (version 73.37)

Entrez gene

2150

UniProt

P55085 (UniProt - Evidence at protein level)

neXtProt

NX_P55085

Antibodypedia

F2RL1 antibodies
 

PROTEIN VIEW

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F2RL1-001
 
F2RL1-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

F2RL1-001 ENSP00000296677
ENST00000296677
P55085
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Show » Show » 397 44.1 Yes 7
F2RL1-002 ENSP00000425622
ENST00000514165
D6RJH3
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Show » Show » 112 12.9 No 3