CASP3

GENE INFORMATION

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Gene name

CASP3 (HGNC Symbol)

Synonyms

apopain, CPP32, CPP32B, Yama

Description

caspase 3, apoptosis-related cysteine peptidase (HGNC Symbol)

Entrez gene summary

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]

Chromosome

4 (Chromosome progress)

Cytoband

q35.1

Chromosome location (bp)

185548850 - 185570663

Ensembl

ENSG00000164305 (version 73.37)

Entrez gene

836

UniProt

P42574 (UniProt - Evidence at protein level)

neXtProt

NX_P42574

Antibodypedia

CASP3 antibodies
 

PROTEIN VIEW

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CASP3-001
 
CASP3-002
 
CASP3-003
 
CASP3-004
 
CASP3-005
 
CASP3-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CASP3-001 ENSP00000311032
ENST00000308394
P42574
Show all »
Show » Show » 277 31.6 No 0
CASP3-002 ENSP00000377210
ENST00000393585
A8MVM1
Show all »
Show » 182 20.5 No 0
CASP3-003 ENSP00000428929
ENST00000523916
P42574
Show all »
Show » Show » 277 31.6 No 0
CASP3-004 ENSP00000407142
ENST00000447121
C9JXR7
Show all »
Show » 117 13.4 No 0
CASP3-005 ENSP00000377213
ENST00000393588
A8MVM1
Show all »
Show » 182 20.5 No 0
CASP3-006 ENSP00000428372
ENST00000517513
A8MVM1
Show all »
Show » 182 20.5 No 0