KLKB1

GENE INFORMATION

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Gene name

KLKB1 (HGNC Symbol)

Synonyms

KLK3

Description

kallikrein B, plasma (Fletcher factor) 1 (HGNC Symbol)

Entrez gene summary

Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients. [provided by RefSeq, Jul 2008]

Chromosome

4 (Chromosome progress)

Cytoband

q35.2

Chromosome location (bp)

187130133 - 187179625

Ensembl

ENSG00000164344 (version 73.37)

Entrez gene

3818

UniProt

P03952 (UniProt - Evidence at protein level)

neXtProt

NX_P03952

Antibodypedia

KLKB1 antibodies
 

PROTEIN VIEW

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KLKB1-001
 
KLKB1-002
 
KLKB1-003
 
KLKB1-004
 
KLKB1-007
 
KLKB1-008
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KLKB1-001 ENSP00000264690
ENST00000264690
P03952
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Show » Show » 638 71.3 Yes 0
KLKB1-002 ENSP00000412366
ENST00000428196
C9J075
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Show » Show » 148 16.6 Yes 0
KLKB1-003 ENSP00000392231
ENST00000414291
C9IYG8
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Show » 107 12 No 0
KLKB1-004 ENSP00000415563
ENST00000446598
C9JCT1
Show all »
Show » 141 15.9 No 0
KLKB1-007 ENSP00000424469
ENST00000513864
E9PBC5
Show all »
Show » Show » 552 61.8 Yes 0
KLKB1-008 ENSP00000426629
ENST00000511608
C9JCT1
Show all »
Show » Show » 686 76.8 No 0