SLC6A18

GENERAL INFORMATION

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Gene name

SLC6A18

Gene description

Solute carrier family 6 (neutral amino acid transporter), member 18

Protein class

Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

Membrane

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (kidney)
GTEx:Tissue enriched (kidney)

Protein evidence

Evidence at protein level

Protein localization

Expression in luminal membrane, kidney. Additional cytoplasmic and membranous expression in epididymis.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 1 antibody.
HPA011885
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Epididymis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (kidney)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (kidney)

Organ

Expression



GENE INFORMATION

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Gene name

SLC6A18 (HGNC Symbol)

Synonyms

FLJ31236, Xtrp2

Description

Solute carrier family 6 (neutral amino acid transporter), member 18 (HGNC Symbol)

Entrez gene summary

The SLC6 family of proteins, which includes SLC6A18, act as specific transporters for neurotransmitters, amino acids, and osmolytes like betaine, taurine, and creatine. SLC6 proteins are sodium cotransporters that derive the energy for solute transport from the electrochemical gradient for sodium ions (Hoglund et al., 2005 [PubMed 16125675]).[supplied by OMIM, Apr 2010]

Chromosome

5

Cytoband

p15.33

Chromosome location (bp)

1225355 - 1246189

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000164363 (version 78.38)

Entrez gene

348932

UniProt

Q96N87 (UniProt - Evidence at transcript level)

neXtProt

NX_Q96N87

Antibodypedia

SLC6A18 antibodies


PROTEIN BROWSER

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ENST00000324642
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SLC6A18-001 ENSP00000323549
ENST00000324642
Q96N87
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