LMTK2

GENE INFORMATION

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Gene name

LMTK2 (HGNC Symbol)

Synonyms

AATYK2, BREK, cprk, KIAA1079, KPI-2, KPI2, LMR2

Description

lemur tyrosine kinase 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009]

Chromosome

7 (Chromosome progress)

Cytoband

q21.3

Chromosome location (bp)

97736197 - 97838945

Ensembl

ENSG00000164715 (version 73.37)

Entrez gene

22853

UniProt

Q8IWU2 (UniProt - Evidence at protein level)

neXtProt

NX_Q8IWU2

Antibodypedia

LMTK2 antibodies
 

PROTEIN VIEW

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LMTK2-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LMTK2-001 ENSP00000297293
ENST00000297293
Q8IWU2
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