CTSB

GENE INFORMATION

? »

Gene name

CTSB

Synonyms

Description

cathepsin B (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

8 (Chromosome progress)

Cytoband

p23.1

Chromosome location (bp)

11700033 - 11726957

Ensembl

ENSG00000164733 (version 73.37)

Entrez gene

1508

UniProt

P07858 (UniProt - Evidence at protein level)

neXtProt

NX_P07858

Antibodypedia

CTSB antibodies
 

PROTEIN VIEW

? »
 
 
 « 
 
CTSB-001
 
CTSB-002
 
CTSB-003
 
CTSB-004
 
CTSB-005
 
CTSB-006
 
CTSB-007
 
CTSB-011
 
CTSB-013
 
CTSB-014
 
CTSB-015
 
CTSB-016
 
CTSB-017
 
CTSB-018
 
CTSB-019
 
CTSB-020
 
CTSB-021
 
CTSB-023
 
CTSB-024
 
CTSB-025
 
CTSB-027
 
CTSB-030
 
CTSB-032
 
CTSB-033
 
CTSB-042
 
CTSB-201
 
CTSB-202
 
 » 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CTSB-001 ENSP00000345672
ENST00000353047
P07858
Show all »
Show » Show » 339 37.8 Yes 0
CTSB-002 ENSP00000432244
ENST00000533455
P07858
Show all »
Show » Show » 339 37.8 Yes 0
CTSB-003 ENSP00000435105
ENST00000530640
P07858
Show all »
Show » Show » 339 37.8 Yes 0
CTSB-004 ENSP00000433215
ENST00000531089
P07858
Show all »
Show » Show » 339 37.8 Yes 0
CTSB-005 ENSP00000434217
ENST00000534510
P07858
Show all »
Show » Show » 339 37.8 Yes 0
CTSB-006 ENSP00000409917
ENST00000453527
P07858
Show all »
Show » Show » 339 37.8 Yes 0
CTSB-007 ENSP00000342070
ENST00000345125
P07858
Show all »
Show » Show » 339 37.8 Yes 0
CTSB-011 ENSP00000436456
ENST00000531551
E9PCB3
Show all »
Show » 110 12.7 Yes 0
CTSB-013 ENSP00000435886
ENST00000531502
E9PS78
Show all »
Show » 92 10.7 Yes 0
CTSB-014 ENSP00000433379
ENST00000527215
E9PL32
Show all »
Show » 68 7.8 Yes 0
CTSB-015 ENSP00000436159
ENST00000534636
E9PQM1
Show all »
Show » 175 19.5 Yes 0
CTSB-016 ENSP00000436074
ENST00000524500
E9PR54
Show all »
Show » 98 11.4 Yes 0
CTSB-017 ENSP00000433995
ENST00000533572
E9PSG5
Show all »
Show » 170 18.9 Yes 0
CTSB-018 ENSP00000436122
ENST00000534149
E9PNL5
Show all »
Show » 143 16.1 Yes 0
CTSB-019 ENSP00000435074
ENST00000530296
E9PLY3
Show all »
Show » 165 18.5 Yes 0
CTSB-020 ENSP00000436627
ENST00000526195
E9PHZ5
Show all »
Show » 149 16.6 Yes 0
CTSB-021 ENSP00000434725
ENST00000527243
E9PNL5
Show all »
Show » 143 16.1 Yes 0
CTSB-023 ENSP00000435260
ENST00000534382
E9PKX0
Show all »
Show » 70 8.1 Yes 0
CTSB-024 ENSP00000432408
ENST00000532392
E9PR00
Show all »
Show » 21 2.4 Yes 0
CTSB-025 ENSP00000432077
ENST00000524654
E9PID0
Show all »
Show » 32 3.7 Yes 0
CTSB-027 ENSP00000431518
ENST00000526645
E9PKQ7
Show all »
Show » 136 15.4 Yes 0
CTSB-030 ENSP00000431143
ENST00000532656
E9PKX0
Show all »
Show » 70 8.1 Yes 0
CTSB-032 ENSP00000433929
ENST00000528965
E9PIS1
Show all »
Show » 55 6.5 Yes 0
CTSB-033 ENSP00000435650
ENST00000505496
E9PJ67
Show all »
Show » 101 11.8 Yes 0
CTSB-042 ENSP00000473301
ENST00000526481
R4GMQ5
Show all »
Show » 76 8.6 No 0
CTSB-201 ENSP00000411254
ENST00000415599
E9PCB3
Show all »
Show » 110 12.7 Yes 0
CTSB-202 ENSP00000415889
ENST00000434271
P07858
Show all »
Show » Show » 339 37.8 Yes 0