COX6C

GENERAL INFORMATION

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Gene name

COX6C

Gene description

Cytochrome c oxidase subunit VIc

Protein class

Cancer-related genes
Mitochondrial proteins
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

8
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic expression in a granular pattern.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA014295 , CAB016244
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

COX6C

Synonyms

Description

Cytochrome c oxidase subunit VIc (HGNC Symbol)

Entrez gene summary

Cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene has been found on chromosomes 16p12. [provided by RefSeq, Jul 2010]

Chromosome

8

Cytoband

q22.2

Chromosome location (bp)

99873200 - 99894062

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000164919 (version 78.38)

Entrez gene

1345

UniProt

P09669 (UniProt - Evidence at protein level)

neXtProt

NX_P09669

Antibodypedia

COX6C antibodies


PROTEIN BROWSER

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ENST00000297564
 
ENST00000517682
 
ENST00000518171
 
ENST00000520271
 
ENST00000520468
 
ENST00000522940
 
ENST00000523016
 
ENST00000524245
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

COX6C-001 ENSP00000428895
ENST00000520468
P09669
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Show » Show » 75 8.8 No 1
COX6C-002 ENSP00000429755
ENST00000518171
P09669
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Show » Show » 75 8.8 No 1
COX6C-003 ENSP00000297564
ENST00000297564
P09669
Show all »
Show » Show » 75 8.8 No 1
COX6C-004 ENSP00000429707
ENST00000523016
P09669
Show all »
Show » Show » 75 8.8 No 1
COX6C-005 ENSP00000429714
ENST00000517682
P09669
Show all »
Show » Show » 75 8.8 No 1
COX6C-006 ENSP00000428965
ENST00000522940
P09669
Show all »
Show » Show » 75 8.8 No 1
COX6C-007 ENSP00000428150
ENST00000520271
P09669
Show all »
Show » Show » 75 8.8 No 1
COX6C-008 ENSP00000429410
ENST00000524245
P09669
Show all »
Show » Show » 75 8.8 No 1