FZD6

GENE INFORMATION

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Gene name

FZD6 (HGNC Symbol)

Synonyms

Hfz6

Description

frizzled family receptor 6 (HGNC Symbol)

Entrez gene summary

This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011]

Chromosome

8 (Chromosome progress)

Cytoband

q22.3

Chromosome location (bp)

104310661 - 104345094

Ensembl

ENSG00000164930 (version 73.37)

Entrez gene

8323

UniProt

O60353 (UniProt - Evidence at protein level)

neXtProt

NX_O60353

Antibodypedia

FZD6 antibodies
 

PROTEIN VIEW

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FZD6-001
 
FZD6-002
 
FZD6-003
 
FZD6-004
 
FZD6-005
 
FZD6-006
 
FZD6-201
 
FZD6-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FZD6-001 ENSP00000429055
ENST00000522566
O60353
Show all »
Show » Show » 706 79.3 Yes 7
FZD6-002 ENSP00000429528
ENST00000523739
O60353
Show all »
Show » Show » 674 75.6 No 7
FZD6-003 ENSP00000427733
ENST00000519011
E5RGK8
Show all »
Show » Show » 60 7 Yes 0
FZD6-004 ENSP00000428301
ENST00000522484
G5EA13
Show all »
Show » Show » 467 53.6 Yes 6
FZD6-005 ENSP00000428188
ENST00000521195
E5RJT4
Show all »
Show » Show » 64 7.3 Yes 0
FZD6-006 ENSP00000428257
ENST00000523933
E5RJG0
Show all »
Show » 100 11.7 No 0
FZD6-201 ENSP00000351605
ENST00000358755
O60353
Show all »
Show » Show » 706 79.3 Yes 7
FZD6-202 ENSP00000443757
ENST00000540287
F5H831
Show all »
Show » Show » 401 44.3 No 4