PDP1

GENE INFORMATION

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Gene name

PDP1 (HGNC Symbol)

Synonyms

PDH, PDP, PPM2C

Description

Pyruvate dehyrogenase phosphatase catalytic subunit 1 (HGNC Symbol)

Entrez gene summary

Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009]

Chromosome

8

Cytoband

q22.1

Chromosome location (bp)

94870035 - 94938294

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000164951 (version 75.37)

Entrez gene

54704

UniProt

Q9P0J1 (UniProt - Evidence at protein level)

neXtProt

NX_Q9P0J1

Antibodypedia

PDP1 antibodies
 

PROTEIN VIEW

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PDP1-001
 
PDP1-002
 
PDP1-004
 
PDP1-006
 
PDP1-007
 
PDP1-008
 
PDP1-009
 
PDP1-010
 
PDP1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PDP1-001 ENSP00000297598
ENST00000297598
Q9P0J1
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Show » Show » 537 61.1 No 0
PDP1-002 ENSP00000428317
ENST00000520728
Q9P0J1
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Show » Show » 537 61.1 No 0
PDP1-004 ENSP00000430380
ENST00000517764
Q9P0J1
Show all »
Show » Show » 537 61.1 No 0
PDP1-006 ENSP00000430931
ENST00000520614
E5RHB9
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Show » Show » 72 8.6 No 0
PDP1-007 ENSP00000430366
ENST00000518107
E5RFL8
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Show » Show » 76 9 No 0
PDP1-008 ENSP00000428433
ENST00000518573
E5RIE5
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Show » Show » 128 14.9 No 0
PDP1-009 ENSP00000430655
ENST00000518827
E5RIV4
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Show » Show » 232 26.5 No 0
PDP1-010 ENSP00000429492
ENST00000521144
E5RI96
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Show » Show » 147 16.8 No 0
PDP1-201 ENSP00000379503
ENST00000396200
Q9P0J1
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Show » Show » 562 63.7 No 0