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GENE INFORMATION
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The gene information section lists the gene name (HUGO Gene Nomenclature Committee ( HGNC) name if available), any approved gene synonyms, Ensembl gene description, and the Entrez gene summary from the National Center for Biotechnology Information.
The chromosomal and cytoband location of the gene according to Ensembl is reported together with the Ensembl gene identifier and Ensembl database version. The Entrez gene identifier for the gene is also given. If any of the protein products of the gene is linked to a UniProt KB/SWISS-PROT entry, links to the UniProt and the neXtProt databases for these proteins are displayed.
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Gene name |
PDP1 (HGNC Symbol) |
Synonyms |
PDH, PDP, PPM2C |
Description |
pyruvate dehyrogenase phosphatase catalytic subunit 1 (HGNC Symbol) |
Entrez gene summary |
Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009] |
Chromosome |
8 (Chromosome progress)
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Cytoband |
q22.1 |
Chromosome location (bp) |
94870035 - 94938294 |
Ensembl |
ENSG00000164951 (version 69.37) |
Entrez gene |
54704 |
UniProt |
Q9P0J1 |
neXtProt |
NX_Q9P0J1 |
Antibodypedia |
PDP1 antibodies |
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PROTEIN VIEW
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The protein view displays protein features. The tabs at the top of the protein view section can be used to switch between the different splice variants encoded by this gene. The mouse over function displays additional data for the features in the protein view.
At the top of the protein view, the maximum percent sequence identity of the protein to all other proteins from other human genes is shown, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) ( read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0 and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green.
Common (purple) and unique (grey) regions between alternative processed transcripts from the same gene are also displayed ( read more), and at the bottom of the protein view is the protein scale.
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PROTEIN INFORMATION
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The protein information section displays the alternative protein-coding transcripts (splice variants) encoded by this gene, according to the Ensembl database.
The ENSP identifier links to the Ensembl website for that protein, and the ENST identifier links to the Ensembl website for that transcript. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes to which this protein has been assigned are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column.
The length of the protein (amino acid residues) (according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0 and Phobius and predicted transmembrane region(s) (according to MDM) are also reported.
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Splice variant |
Ensembl |
UniProt |
Protein class |
Gene ontology |
Length (aa) |
Molecular mass (kDa) |
Signal peptide (predicted) |
Transmembrane regions (predicted)
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| PDP1-001 |
ENSP00000297598
ENST00000297598
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Q9P0J1 Show all »
« Hide
Q9P0J1 [Direct mapping][Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial B3KPZ7 [Target identity:99%; Query identity:100%]cDNA FLJ32517 fis, clone SMINT1000117, highly similar to Pyruvate dehydrogenase (lipoamide)-phosphatase 1 E5RIV4 [Target identity:43%; Query identity:100%][Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial E5RI96 [Target identity:27%; Query identity:100%][Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial E5RIE5 [Target identity:23%; Query identity:100%][Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial E5RFL8 [Target identity:14%; Query identity:100%][Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial E5RHB9 [Target identity:13%; Query identity:100%][Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
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Enzymes Hydrolases Potential transmembrane proteins SPOCTOPUS predicted membrane proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level
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537 |
61.1 |
No |
0 |
| PDP1-002 |
ENSP00000428317
ENST00000520728
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Q9P0J1 Show all »
« Hide
Q9P0J1 [Direct mapping][Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial B3KPZ7 [Target identity:99%; Query identity:100%]cDNA FLJ32517 fis, clone SMINT1000117, highly similar to Pyruvate dehydrogenase (lipoamide)-phosphatase 1 E5RIV4 [Target identity:43%; Query identity:100%][Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial E5RI96 [Target identity:27%; Query identity:100%][Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial E5RIE5 [Target identity:23%; Query identity:100%][Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial E5RFL8 [Target identity:14%; Query identity:100%][Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial E5RHB9 [Target identity:13%; Query identity:100%][Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
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Show »
« Hide
Enzymes Hydrolases Potential transmembrane proteins SPOCTOPUS predicted membrane proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level
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Show »
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537 |
61.1 |
No |
0 |
| PDP1-004 |
ENSP00000430380
ENST00000517764
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Q9P0J1 Show all »
« Hide
Q9P0J1 [Direct mapping][Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial B3KPZ7 [Target identity:99%; Query identity:100%]cDNA FLJ32517 fis, clone SMINT1000117, highly similar to Pyruvate dehydrogenase (lipoamide)-phosphatase 1 E5RIV4 [Target identity:43%; Query identity:100%][Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial E5RI96 [Target identity:27%; Query identity:100%][Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial E5RIE5 [Target identity:23%; Query identity:100%][Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial E5RFL8 [Target identity:14%; Query identity:100%][Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial E5RHB9 [Target identity:13%; Query identity:100%][Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
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Show »
« Hide
Enzymes Hydrolases Potential transmembrane proteins SPOCTOPUS predicted membrane proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level
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Show »
« Hide
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537 |
61.1 |
No |
0 |
| PDP1-006 |
ENSP00000430931
ENST00000520614
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E5RHB9 Show all »
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E5RHB9 [Target identity:100%; Query identity:100%][Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
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72 |
8.6 |
No |
0 |
| PDP1-007 |
ENSP00000430366
ENST00000518107
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E5RFL8 Show all »
« Hide
E5RFL8 [Target identity:100%; Query identity:100%][Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial E5RHB9 [Target identity:94%; Query identity:100%][Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
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76 |
9 |
No |
0 |
| PDP1-008 |
ENSP00000428433
ENST00000518573
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E5RIE5 Show all »
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E5RIE5 [Target identity:100%; Query identity:100%][Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial E5RFL8 [Target identity:59%; Query identity:100%][Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial E5RHB9 [Target identity:56%; Query identity:100%][Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
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128 |
14.9 |
No |
0 |
| PDP1-009 |
ENSP00000430655
ENST00000518827
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E5RIV4 Show all »
« Hide
E5RIV4 [Target identity:100%; Query identity:100%][Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial E5RI96 [Target identity:63%; Query identity:100%][Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial E5RIE5 [Target identity:55%; Query identity:100%][Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial E5RFL8 [Target identity:32%; Query identity:100%][Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial E5RHB9 [Target identity:31%; Query identity:100%][Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
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232 |
26.5 |
No |
0 |
| PDP1-010 |
ENSP00000429492
ENST00000521144
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E5RI96 Show all »
« Hide
E5RI96 [Target identity:100%; Query identity:100%][Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial E5RIE5 [Target identity:87%; Query identity:100%][Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial E5RFL8 [Target identity:51%; Query identity:100%][Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial E5RHB9 [Target identity:48%; Query identity:100%][Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
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Show »
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147 |
16.8 |
No |
0 |
| PDP1-201 |
ENSP00000379503
ENST00000396200
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Q9P0J1 Show all »
« Hide
Q9P0J1 [Direct mapping][Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial B4DYX8 [Target identity:100%; Query identity:95%]cDNA FLJ56179, highly similar to Pyruvate dehydrogenase (lipoamide)-phosphatase 1 Q6P1N1 [Target identity:100%; Query identity:92%]PPM2C protein B3KPZ7 [Target identity:95%; Query identity:100%]cDNA FLJ32517 fis, clone SMINT1000117, highly similar to Pyruvate dehydrogenase (lipoamide)-phosphatase 1 E5RIV4 [Target identity:41%; Query identity:100%][Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial E5RI96 [Target identity:26%; Query identity:100%][Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial E5RIE5 [Target identity:22%; Query identity:100%][Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial E5RFL8 [Target identity:13%; Query identity:100%][Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial E5RHB9 [Target identity:12%; Query identity:100%][Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
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Show »
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Enzymes Hydrolases Potential transmembrane proteins SPOCTOPUS predicted membrane proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level
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Show »
« Hide
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562 |
63.7 |
No |
0 |
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